RISK STRATIFICATION OF DLBCL WITH MVED2 SCORE USING INTEGRATIVE HOST ADIPOSE DENSITY AND METABOLIC TUMOR CHARACTERISTICS COMPARED TO OTHER INDEXES

Introduction: The prognosis of diffuse large B-cell lymphoma (DLBCL) is assessed by the International Prognostic Index (IPI). Since 1993 developments in diagnosis and therapy have improved DLBCL, especially for high-risk groups. Although IPI remains prognostic, its ability to estimate treatment failure has reduced. FDG-PET-CT been routinely implemented evaluate extent at baseline metabolic response during treatment. At baseline, also quantifies more accurately tumor burden two measures, total volume (TMTV) distance between 2 lesions (SDmax), a host parameter, lumbar subcutaneous adipose density (LSAD). We recently demonstrated that MVED2 score (TMTV, ECOG PS, SDMax, LSAD) allowed discriminate very DLBCL pts. aim this analysis was compare performance other prognostic scores NCCN IPI, international index (IMPI), ECOG/TMTV score. Methods: Pts were included REMARC study (NCT01122472), >60–80 years old, responder R-CHOP randomized lenalidomide or placebo maintenance. discriminatory power measured C-index compared (0.59 (if TMTV > 220) + 0.57 PS ≥ 2) 0.76 SDMax 32) 0.70 LSAD −90)) scores. Results: 273 patients analyzed. According score, 10% classified into category, 38% (4–5) 14% IMPI, ECOG-PS had significant impact on PFS (p < 0.001) OS 0.001). better identification pts with shorter than did displayed higher model scores, showing both (Table 1). Conclusion: outperforms TMTV/ECOG enables individualized estimates outcome. *H risk event/total—** L I without PFS/total—*** 95% CI Keyword: models No conflicts interests pertinent abstract.